Polyglycolic acid
Polyglycolic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| perseris | New Drug Application | 2025-01-28 |
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Clinical
Clinical Trials
2472 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 92 | 265 | 144 | 6 | 12 | 475 |
| Neoplasms | D009369 | — | C80 | 109 | 78 | 30 | 2 | 6 | 204 |
| Rectal neoplasms | D012004 | — | — | 30 | 93 | 37 | 1 | 4 | 157 |
| Adenocarcinoma | D000230 | — | — | 39 | 90 | 30 | 1 | 1 | 145 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 23 | 83 | 23 | 3 | 21 | 141 |
| Colonic neoplasms | D003110 | — | C18 | 29 | 66 | 52 | 1 | 4 | 140 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | 4 | 11 | 10 | 53 | 78 |
| Lymphoma | D008223 | — | C85.9 | 19 | 40 | 17 | 1 | 6 | 77 |
| Esophageal neoplasms | D004938 | — | C15 | 13 | 47 | 6 | 1 | 4 | 64 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 9 | 26 | 19 | 7 | 5 | 63 |
Show 138 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 59 | 103 | 28 | — | 4 | 167 |
| Leukemia | D007938 | — | C95 | 19 | 48 | 30 | — | 7 | 93 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 25 | 54 | 18 | — | 1 | 90 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 13 | 39 | 29 | — | 4 | 77 |
| Lymphoid leukemia | D007945 | — | C91 | 11 | 31 | 26 | — | 4 | 64 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 34 | 29 | 8 | — | 3 | 64 |
| Carcinoma | D002277 | — | C80.0 | 19 | 28 | 14 | — | 3 | 55 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 11 | 27 | 17 | — | 4 | 52 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 21 | 15 | 6 | — | 2 | 39 |
| Lung neoplasms | D008175 | — | C34.90 | 13 | 19 | 4 | — | 4 | 36 |
Show 211 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | 1 | — | — | 17 | 27 |
| Osteosarcoma | D012516 | — | — | 7 | 6 | — | — | 3 | 15 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | 3 | — | — | 11 | 15 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 10 | 10 | — | — | — | 14 |
| Triple negative breast neoplasms | D064726 | — | — | 10 | 7 | — | — | — | 13 |
| Sarcoma | D012509 | — | — | 6 | 6 | — | — | 1 | 13 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 11 | 3 | — | — | — | 12 |
| Myelodysplastic syndromes | D009190 | — | D46 | 8 | 4 | — | — | — | 11 |
| Aging | D000375 | GO_0007568 | R41.81 | — | 2 | — | — | 9 | 11 |
| Acinar cell carcinoma | D018267 | — | — | 7 | 5 | — | — | — | 10 |
Show 162 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 5 | — | — | — | 1 | 6 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 5 | — | — | — | — | 5 |
| Atrophy | D001284 | — | — | 1 | — | — | — | 4 | 5 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 3 | — | — | — | 1 | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | — | — | — | 2 | 4 |
| Adenocarcinoma of lung | D000077192 | — | — | 2 | — | — | — | 1 | 3 |
| Sezary syndrome | D012751 | — | C84.1 | 3 | — | — | — | — | 3 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | — | 2 | 3 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | 1 | 2 |
| Pseudomyxoma peritonei | D011553 | EFO_0007456 | — | 1 | — | — | — | 1 | 2 |
Show 51 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gyrate atrophy | D015799 | — | — | — | — | — | — | 12 | 12 |
| Growth disorders | D006130 | — | — | — | — | — | — | 11 | 11 |
| Eclampsia | D004461 | — | O15 | — | — | — | — | 6 | 6 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 6 | 6 |
| Chronic pain | D059350 | — | — | — | — | — | — | 5 | 5 |
| Avitaminosis | D001361 | EFO_0005878 | E56.9 | — | — | — | — | 5 | 5 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 5 | 5 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | — | 5 | 5 |
| Feeding behavior | D005247 | — | — | — | — | — | — | 5 | 5 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 4 | 4 |
Show 230 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Polyglycolic acid |
| INN | polyglycolic acid |
| Description | Polyglycolide or poly(glycolic acid) (PGA), also spelled as polyglycolic acid, is a biodegradable, thermoplastic polymer and the simplest linear, aliphatic polyester. It can be prepared starting from glycolic acid by means of polycondensation or ring-opening polymerization. PGA has been known since 1954 as a tough fiber-forming polymer. Owing to its hydrolytic instability, however, its use has initially been limited. Currently polyglycolide and its copolymers (poly(lactic-co-glycolic acid) with lactic acid, poly(glycolide-co-caprolactone) with ε-caprolactone and poly (glycolide-co-trimethylene carbonate) with trimethylene carbonate) are widely used as a material for the synthesis of absorbable sutures and are being evaluated in the biomedical field.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 26009-03-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107965 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | H1IL6F7KB8 (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
Black-box warning for: Perseris
Adverse Events
Top Adverse Reactions
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51 adverse events reported
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